Comprehensive disease control (CDC): what does achieving CDC mean for patients with rheumatoid arthritis?

Comprehensive disease control (CDC): what does achieving CDC mean for patients with rheumatoid arthritis?

BACKGROUND This study assessed the impact of simultaneous achievement of clinical, functional and structural efficacy, herein referred to as comprehensive disease control (CDC), on short-term and long-term work-related outcomes, health-related quality of life (HRQoL), pain and fatigue. METHODS Data were pooled from three randomised trials of adalimumab plus methotrexate for treatment of early...

[Centers for Disease Control and Prevention (CDC)].

Achieving comprehensive disease control in patients with early and established rheumatoid arthritis treated with adalimumab plus methotrexate versus methotrexate alone

OBJECTIVE To evaluate the achievement of comprehensive disease control (CDC) following 1 year of treatment with adalimumab+methotrexate versus methotrexate alone and whether early achievement of remission (at week 24 or 26) is associated with CDC at week 52 in patients with either early or established rheumatoid arthritis (RA). METHODS Post hoc analyses were conducted in three clinical studie...

What do microRNAs mean for rheumatoid arthritis?

MicroRNAs (miRNAs) are small noncoding RNA molecules that modulate the expression of multiple protein-encoding genes at the posttranscription level. They likely participate in nearly every developmental and physiologic process. Although the function of most mammalian miRNAs has yet to be determined, it appears that their aberrant expression may play a role in the pathogenesis of several patholo...

Establishment of a cell model for screening antibody drugs against rheumatoid arthritis with ADCC and CDC.

TNFα played a dominant role in the development and progression of rheumatoid arthritis (RA). Clinical trials proved the efficacies of anti-TNFα agents for curing RA. However, most researchers were concentrating on their abilities of neutralizing TNFα, the potencies of different anti-TNFα agents varied a lot due to the antibody-dependent cell-mediated cytotoxicity (ADCC) or complement dependent ...